PCABioScience, LLC was founded in June of 2021 by Dr. Lanny Johnson. The purpose was to have a place to house his intellectual property resulting from 15 years of research and development on a new reagent; protocatechuic acid (PCA for short). View Intellectual Property Here.
Dr. Johnson is an internationally recognized orthopedic surgeon. His primary clinical contribution was as one of the pioneers of arthroscopic surgery. He had multiple surgical inventions as well as contributing innovative surgical procedures for treatment of synovial joints; knee, shoulder, elbow, and hip. He published many articles concerning such and authored several textbooks related to his clinical practice. (C.V)
Since concluding his clinical practice, he has been devoted to research and development, specifically for protocatechuic acid.
This has resulted in multiple US patients and extensions internationally specifically for his discovery of protocatechuic acid, a pharmaceutical reagent that has many amazing properties.
- Broad Spectrum Antibiotic
- Biofilm destroyer
- Local growth factor stimulator
- Wound healing accelerator
- Inactivates COVID19 virus. [link to viral page]
- Coating of masks and personal protective equipment.
The Journey: Dr. Johnson saw an article in a Lansing Michigan newspaper in 2005 that reported on the studies of Michigan State University scientists. They reported that the dyes of cherries placed upon the pancreas cells of a rodent resulted in production of insulin, the natural function of such cells.
This prompted him to consider whether these plant dyes would induce hormonal expression in other tissues; specifically, the synovium of human joint lining. Testing at independent contract laboratory confirmed such. This resulted in US patent 8, 263, 069. At the same time, it was learned that the reactive agent was not the parent dye known as cyanidin-3-glucoside but PCA when subject to carbon labeling.
Vitaglione, P., Donnarumma, G., Napolitano, A., Galvano, F. et al., Protocatechuic acid is the major human metabolite of cyanidin-glucoside. J. Nutr. 2007, 137, 2043–2048.
The next step was an animal study at independent contract laboratories in Maryland. These showed that oral administration of PCA to rabbits caused their joint lining to produce PCA and cause healing of a surgically induced arthritis. A patent application was submitted years ago and is still under review on technicalities.
While waiting on this patent application, Dr. Johnson searched the literature for other potential applications of PCA. He saw that raw plant extracts with many ingredients had antibiotic properties as reported in Asian medicine. Some of these has PCA as one of many other ingredients.
He then designed research studies for another independent laboratory in Michigan, his home state. These studies on rodent wounds contaminated with MRSA and Pseudomonas bacteria were decontaminated in 2 days of the infection. Surprisingly, the wound was also healed. Further study showed the wound was completely healed, but showed a layer of collagen in the skin, not seen in the control animals.
The following microscopic evidence of collagen production in the superficial wound of a rodent. The photomicrograph on the left is lower power than the one on the right. Both had the superficial skin stripped off to produce the wound. It was to replicate the clinical condition of dermabrasion or exfoliation.
The evidence of collagen formation even as early as two days was seen by a special trichrome dye. The blue color represents collagen formation. It is not seen the untreated, but very evident on the right photomicrograph of the protocatechuic acid topical treatment of the wound.
